Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 11, Issue 8, Pages 973-1011Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802611795347627
Keywords
Ischaemia; CNS; glia; neurones; neurodegeneration; neuropathology; purinergic transmission
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Funding
- Alzheimer's Research Trust (UK)
- National Institute of Health (NIH)
- Grant Agency of the Czech Republic [GACR 309/08/1381, GACR 305/08/1384]
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There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X receptors are involved in fast synaptic transmission and synaptic plasticity. P2Y receptors largely mediate presynaptic activities. Both P1 and P2 receptors participate in neurone-glia interactions. Purinergic signalling is involved in control of cerebral vascular tone and remodelling. Examples of the roles of purinoceptors in neuropathology involve: A(2A) receptors in Parkinson's disease and epilepsy, P2 receptors in trauma, ischaemia, neuroinflammatory and neuropsychiatric disorders, and neuropathic pain.
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