Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 9, Issue 12, Pages 1088-1097Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802609789630839
Keywords
RNAi; siRNA; peptide; gene therapy; delivery systems
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Foundation for Innovation (CFI)
- Canadian Research Chairs (CRC)
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Applying RNA interference to silence a specific gene has opened a new and promising avenue of gene therapy. But a key bottleneck is the poor stability and inability of naked siRNA to translocate through cell membranes. Among several delivery systems, cationic peptides capable of penetrating cell membranes have drawn attention due to their structural and functional versatility, potential biocompatibility and ability to target cells. In this review, different classes of peptides employed in siRNA delivery are reviewed. In particular, a new class of siRNA delivery peptides with high transfection efficiency and low cytotoxicity is introduced.
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