Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 8, Issue 9, Pages 750-765Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802608784535048
Keywords
SGRM; glucocorticoid; nonsteroidal; modulator; transactivation; transrepression; dissociated; inflammation; multiple myeloma
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Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.
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