Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 8, Issue 10, Pages 859-868Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802608784911644
Keywords
Hsp90; anti-cancer; structure-based design
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Heat shock protein (Hsp90) inhibitors are an increasingly interesting and important class of compounds where the first in class, natural product derived inhibitors such as 17-allylaminogeldanamycin (17-AAG), are entering late stage clinical development. Recently the emergence of synthetic, small molecule inhibitors has been described and both NVP-AUY922 and BIIB021 have entered clinical development. The medicinal chemistry of these and other published small molecule Hsp90 inhibitors is described in this review.
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