Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 13, Issue 8, Pages 816-830Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920312804871175
Keywords
NMR; molecular modeling; protein-ligand interactions; drug targeting
Categories
Funding
- MINECO [CTQ2009-08536, CTQ2012-32025]
- EU through the GlycoHit
- EU through ITN-Glycopharm
- EU through COST actions [BM1003, CM1102]
- EU through Comunidad de Madrid
- FCT-Portugal [SFRH/BPD/65462/2009]
- FPI fellowship
- JAE-Doc fellowship
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/65462/2009] Funding Source: FCT
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Diseases that result from infection are, in general, a consequence of specific interactions between a pathogenic organism and the cells. The study of host-pathogen interactions has provided insights for the design of drugs with therapeutic properties. One area that has proved to be promising for such studies is the constituted by carbohydrates which participate in biological processes of paramount importance. On the one hand, carbohydrates have shown to be information carriers with similar, if not higher, importance than traditionally considered carriers as amino acids and nucleic acids. On the other hand, the knowledge on molecular recognition of sugars by lectins and other carbohydrate-binding proteins has been employed for the development of new biomedical strategies. Biophysical techniques such as X-Ray crystallography and NMR spectroscopy lead currently the investigation on this field. In this review, a description of traditional and novel NMR methodologies employed in the study of sugar-protein interactions is briefly presented in combination with a palette of NMR-based studies related to biologically and/or pharmaceutically relevant applications.
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