Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 20, Issue 15, Pages 2557-2579Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13816128113199990482
Keywords
Aerobic glycolysis; cancer metabolism; glutaminolysis; metabolic reprogramming; tumor microenvironment
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Funding
- Spanish Ministry of Economoy and Competitiveness [SAF2011-26518, SAF2010-17573, PI12/01096 PS09/02216]
- PAIDI, Andalusia, Spain [PIE P08-CTS-3759, CVI-6656, CVI-06585]
- Health and Welfare Counsel, Andalusian Government, Spain [PI00825/2010]
- Ministerio de Educacion, Cultura y Deporte
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Tumor cells suffer a metabolic reprogramming which allows them to use metabolic fuels (glucose, glutamine, lipids) through anabolic fates to support their enhanced proliferation and other carcinogenesis-related features. The present review tries to address and summarize the broad and growing information available about this reprogramming, whose pieces, put together, make up a complex scheme that encompasses different complexity scales, from cells to systemic networks.
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