Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 20, Issue 33, Pages 5298-5308Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612820666140128220152
Keywords
Circulating tumor cells; metastasis; thrombosis; microRNA; anticoagulation
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Funding
- National Cancer Institute [2R01CA109035, 1R0CA169603, CA16672]
- Cancer Prevention and Research Institute of Texas (CPRIT) [RP110252, RP130389]
- American Cancer Society [RSG-09-277-01-CSM]
- James S. McDonnell Foundation 21st Century Science Initiative in Brain Cancer Research Award [220020318]
- Science and Technology Development Foundation from Pudong New District, Shanghai, People's Republic of China [PKJ2012-Y11]
- Outstanding Young Foundation from Pudong New District, Shanghai, People's Republic of China [PWRq2011-16]
- Natural Science Foundation of China [81071664]
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Metastasis and thrombosis are serious threats to cancer patients and generally associated with poor prognosis. The elusive mechanisms underlying the pathogenesis of metastasis and thrombosis have been subjects of extensive investigations. The presence of circulating tumor cells (CTCs) is closely related to tumor metastasis, and these cells play an important role in thrombosis in cancer patients. In this review, we describe the latest findings on the role of CTCs in tumor metastasis and cancer-related thrombosis and the regulatory role of microRNAs in CTCs and thrombosis. Additionally, we discuss anticoagulant-based strategies for the prevention of thrombosis and reduction of cancer metastasis and the potential to translate current knowledge on these strategies to the treatment of cancer.
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