Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 20, Issue 41, Pages 6489-6509Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612820666140630094300
Keywords
G-quadruplex ligand; G-quadruplex structure; Telomere
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Funding
- Italian Ministry of Education [20105YY2HL]
- University of Padova [CPDA114388]
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The discovery of novel nucleic acid folding architectures bears a twofold interest related to the structural properties of unprecedented forms and to their functional significance. In addition, physiologically and pathologically important processes can be impaired by endogenous or xenobiotic ligands interacting with specific target sequences. In this paper we will focus on recent advances in the study of telomeric G-quadruplex DNA and RNA structures and the rational design and development of synthetic ligands aimed at pharmacological applications.
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