Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 20, Issue 7, Pages 1045-1050Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13816128113199990419
Keywords
The hypothalamic-pituitary-adrenocortical axis; glucocorticoids; dexamethasone; gastric mucosa; stress; indomethacin; injury; gastroprotection
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Funding
- Program of Presidium RAS 7P [RFBR-13-04-01680-a]
- Program of Presidium RAS 5P [RFBR-13-04-01680-a]
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Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological ulcerogenic effect.
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