Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 18, Issue 8, Pages 1131-1147Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161212799315786
Keywords
Alzheimer disease; amyloid-beta; tau; transgenic mouse models
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Funding
- NIA NIH HHS [R01 AG021982] Funding Source: Medline
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Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.
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