Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 17, Issue 22, Pages 2331-2351Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161211797052574
Keywords
Nanotechnology; magnetic nanoparticles; superparamagnetic iron oxide; surface modification; targeting therapy; drug delivery
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Funding
- National Science Council of Taiwan [NSC 99-2320-B-037-002, NSC 98-2221-E-037-001-MY3]
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Magnetic nanoparticles (MNPs) have been designed for multifaceted applications such as contrast agents in magnetic resonance imaging (MRI) diagnosis, drug/gene carriers for different kinds of therapeutic agents, tissue repair, hyperthermia, immunoassay, and cell separation/sensing. This review highlights synthesis methods, stabilizers used for surface coating on MNPs, and target ligands for ferrying payloads to an interested disease area. Some of the recent biomedical applications of MNPs in the field of drug and DNA targeting delivery are extensively reviewed.
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