Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 16, Issue 38, Pages 4185-4193Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161210794519093
Keywords
Pattern recognition; Toll like receptors; RIG-I like receptor; protein kinase R; teleost fish
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Funding
- Biotechnology and Biological Sciences Research Council [BB/C506021/1] Funding Source: Medline
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Vertebrates are armed with an array of pattern recognition receptors (PRRs) to sense viral pathogen associated molecular patterns (PAMPs). Upon activation, the PRRs trigger an interferon response which is central to host antiviral defence. Recent studies have demonstrated that the PRR surveillance system is well conserved in vertebrates during evolution. In fact, most classical PRRs characterised in mammals, such as Toll like receptors and the RIG-I-like receptors, have been identified in lower vertebrates. This review summarises recent progress in PRR recognition of viral PAMPs in teleost fish.
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