Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 16, Issue 16, Pages 1826-1842Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161210791208983
Keywords
Thiazolidine; thiazolidinone; natural products; anticancer; combinatorial library approach
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Funding
- National Science Foundation of China [90913006]
- National Cancer Institute in U.S. [P30CA021765]
- American Lebanese Syrian Associated Charities (ALSAC)
- St. Jude Children's Research Hospital
- NATIONAL CANCER INSTITUTE [P30CA021765] Funding Source: NIH RePORTER
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Nature makes many pharmacologically active compounds containing thiazolidine and thiazolidinone scaffolds. These privileged structures have been identified in many random screening assays. Molecules containing these core structures have been designed and synthesized, and they show a broad range of anticancer activities in vitro and in vivo. The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds.
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