Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 15, Issue 3, Pages 231-239Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201015666140617094320
Keywords
Biomacromolecules; cell-penetrating peptide; intranasal delivery; non-invasive delivery; percutaneous delivery; topical administration
Funding
- National Basic Research Program of China (973 Program) [2014CB931900, 2013CB932503]
- NSFC, China [81172996, 81373357]
- Sunchon National University Research Fund - Suncheon Research Center for Natural Medicines
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Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.
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