Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 11, Issue 2, Pages 198-215Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920110790909641
Keywords
Protein misfolding; neuroprotection; proteinopathies; molecular chaperones
Funding
- Medical Research Council (MRC, UK)
- BBSRC
- Gerald Kerkut Trust
- University of Southampton
- Medical Research Council [G120/881] Funding Source: researchfish
- MRC [G120/881] Funding Source: UKRI
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Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (proteinopathies). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimer's-and Parkinson's disease, the polyglutamine-and prion disorders and Amyotrophic Lateral Sclerosis.
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