Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 10, Issue 2, Pages 185-191Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920109787315088
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Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions between the stroma and neoplastic cells are largely unexplored. Initial therapies aimed at disrupting angiogenesis within the tumor microenvironment have met with success in a number of tumor types. An improved understanding of stromal signaling pathways is likely to identify additional novel therapeutic targets.
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