Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 9, Issue 4, Pages 246-248Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920108785161550
Keywords
hyaluronic acid; synthase; Pasteurella; size control; molecular mass
Funding
- National Science Foundation
- Oklahoma Center for Advancement of Science and Technology
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In many cases, the cellular response to hyaluronan (HA) depends on the molecular weight (MW) of the polymer chain. Most HA preparations from Nature or its derivatives possess wide size distributions called polydisperse. New chemoenzymatic synthesis technology allows the production of very narrow size distribution polymers called monodisperse. The use of stoichiometrically controlled and synchronized polymerization reactions allows an assortment of new HA reagents in the range of 10 kDa to 2,500 kDa for answering HA biology questions or potentially treating disease.
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