Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 9, Issue 3, Pages 200-209Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920108784567308
Keywords
RNase A; RNase A dimers; RNase A oligomers; cytotoxicity; RNase cytotoxicity; cytotoxicity of oligomeric RNase A; antitumor therapy; 3D domain swapping
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After a short introduction with some examples of cytotoxic ribonucleases, the importance of natural or artificial dimerization ( oligomerization) as a way for a ribonuclease to acquire novel functional properties has been pointed out. In particular, the role of the three dimensional domain swapping mechanism in bovine pancreatic ribonuclease A oligomerization, as well as its impact for the acquisition of novel biological functions ( among which a remarkable antitumor action) by the enzyme protein in oligomeric form have been discussed. Finally, the structural and functional features that could explain why oligomeric ribonuclease A becomes able to display a cytotoxic activity, and the possible use and limits of the three dimensional domain-swapped oligomers of ribonuclease A as anticancer therapeutic agents have been described and discussed.
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