Journal
CURRENT PAIN AND HEADACHE REPORTS
Volume 17, Issue 9, Pages -Publisher
SPRINGER
DOI: 10.1007/s11916-013-0361-8
Keywords
Central sensitization; Chronic pain; Conditioned pain modulation (CPM); Personalized pain medicine; Neuropathic pain; Pain facilitation; Pain inhibition; Psychophysics
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Funding
- Medoc Ltd.
- Israeli Scientific Foundation (ISF) [147/08]
- IIT from Eli Lilly Inc.
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Psychophysical evaluation of endogenous pain inhibition via conditioned pain modulation (CPM) represents a new generation of laboratory tests for pain assessment. In this review we discuss recent findings on CPM in neuropathic pain and refer to psychophysical, neurophysiological, and methodological aspects of its clinical implications. Typically, chronic neuropathic pain patients express less efficient CPM, to the extent that incidence of acquiring neuropathic pain (e.g. post-surgery) and its intensity can be predicted by a pre-surgery CPM assessment. Moreover, pretreatment CPM evaluation may assist in the correct choice of serotonin-noradrenalin reuptake inhibitor analgesic agents for individual patients. Evaluation of pain modulation capabilities can serve as a step forward in individualizing pain medicine.
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