Journal
CURRENT ORGANIC SYNTHESIS
Volume 11, Issue 5, Pages 647-675Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570179411666140530210314
Keywords
1,2,3-triazoles; azides; bis-1,2,3-triazoles; click reaction; cycloaddition; heterocycles; fused 1,2,3-triazoles
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Funding
- Alzahra Research Council
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Triazoles and their derivatives have been widely utilized as precursors in the syntheses of biologically active systems such as anticancers, antimicrobials, antifungals and other cytotoxic active agents. In this review, we tried to highlight the recent advances (2010-2013) in the syntheses of 1,2,3-triazoles, bis-1,2,3-triazoles and fused triazoles via click reaction. Click reaction provides substances quickly and reliably by combining small units together. Click chemistry can also be applied widely for the syntheses of biologically active compounds. Since the 1,2,3-triazole scaffold is present in many beneficial biologically structures, we hope this review attracts the attentions of synthetic organic chemists to make use of the advantages of click reaction in the total syntheses of natural products containing 1,2,3-triazoles.
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