Journal
CURRENT ORGANIC SYNTHESIS
Volume 11, Issue 3, Pages 454-460Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/15701794113109990002
Keywords
Dehydrodimerization; dehydrotrimerization; electrogenerated bases; homocoupling; pyrazolone
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Funding
- National Natural Science Foundation of China [21272021]
- National Basic Research Program of China [2009CB930200]
- National Key Technology RD Program [2011BAD23B01]
- Beijing Natural Science Foundation [7112008]
- Beijing City Education Committee [KM201010005009]
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Electrogenerated base induced dehydrocoupling of pyrazol-5-ones was investigated. The results showed that dehydrodimers and dehydrotrimers were generated simultaneously under electrolytic conditions, and their ratio was mainly dependent on the reaction temperature and the nature of the supporting electrolyte. It was observed that the formation of dimer 2 is preferred at lower temperatures and that trimer 3 is preferentially formed at higher temperatures. In addition, higher yields of 3 could be obtained when NaI was used as the supporting electrolyte. The dehydrocoupling reaction of pyrazol-5-ones to form dimer 2 and trimers 3 and 4 was proposed to be through an EGB-induced cascade mechanism.
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