Journal
CURRENT ORGANIC SYNTHESIS
Volume 9, Issue 6, Pages 873-897Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017912803901619
Keywords
Cascade reaction; multicomponent reaction; one-pot synthesis; tandem reaction; telescoping
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Compared with conventional batch-wise process, one-pot synthesis is the condensation of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, or telescoping synthetic steps. This review summarizes recent progresses in this field, covering mainly four approaches developed for the application towards one-pot organic synthesis.
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