Journal
CURRENT ORGANIC SYNTHESIS
Volume 6, Issue 3, Pages 219-238Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017909788921907
Keywords
Transition metal; cycloaddition; bicyclic alkene; alkyne; cyclobutene
Categories
Funding
- Merck Frosst Centre for Therapeutic Research
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Boehringer Ingelheim (Canada) Ltd
Ask authors/readers for more resources
Transition metal-catalyzed [2+2] cycloadditions between bicyclic alkenes and alkynes provides an efficient method for the construction of cyclobutene rings. Various transition metal complexes, including those of cobalt, nickel, ruthenium, rhodium, and rhenium, have been used to catalyze [2+2] cycloadditions between bicyclic alkenes and alkynes. The purpose of this review is to summarize and discuss the various aspects of transition metal-catalyzed [2+2] cycloaddition between bicyclic alkenes and alkynes, including the development of metal catalysts, the mechanisms of the cycloadditions catalyzed by different metal catalysts, the reactivity of the alkene and the alkyne components in the cycloaddition, the compatibility of different functional groups on the alkene and the alkyne components, the chemo-and regioselectivity of the cycloadditions between unsymmetrical substrates, and the asymmetric induction studies using chiral auxilliaries on the alkyne component in addition to the use of using chiral ligands. The scope and limitations of each catalyst in the [2+2] cycloadditions will also be discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available