Journal
CURRENT ORGANIC CHEMISTRY
Volume 18, Issue 2, Pages 260-289Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138527281802140129104218
Keywords
beta-amino ketones; amino alcohols; conjugate additions; diastereoselectivity; enantioselectivity; Mannich addition
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Funding
- La Trobe University
- NHMRC [1010326]
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beta-Amino ketones are of increasing interest owing to their utility as important synthetic precursors in the synthesis of bioactive molecules and natural products. As a result numerous syntheses of beta-amino ketones have emerged in recent years. Of particular signifi-cance are those methods that allow access to stereopure beta-amino ketones. This review highlights recent advances in stereoselective syntheses of beta-amino ketones and also illustrates the importance of beta-amino ketones as useful synthons.
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