Journal
CURRENT ORGANIC CHEMISTRY
Volume 15, Issue 3, Pages 296-327Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138527211794072551
Keywords
Enantioselective synthesis; organocatalysis; functionalized carbonyl compounds; alpha amino acids; alpha-amino alcohols; alpha-halogenated carbonyl compounds
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Funding
- Spanish Ministerio Ciencia e Innovacion [CSD2007-00006, CTQ2007-5218/BQU]
- Generalitat Valenciana [2009/039]
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This review covers literature on organocatalyzed enantioselective alpha-heterofunctionalization of carbonyl compounds from 2006 to 2009. In this review, we will consider those reactions in which a new carbon-heteroatom bond is formed using a chiral organic molecule as catalyst, excluding those processes, which involve the modification on the hybridization of a previously functionalized carbonyl compound. Using this straightforward synthetic strategy, a wide range of valuable chiral building blocks such as alpha-amino acids, alpha-amino alcohols, epoxides, 1,2-diols, alpha-sulfenylated, alpha-selenenylated and alpha-halogenated carbonyl derivatives can be obtained by this simple and advantageous methodology.
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