Journal
CURRENT OPINION IN UROLOGY
Volume 20, Issue 3, Pages 204-210Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOU.0b013e3283384101
Keywords
outcomes; prognosis; prostate cancer; survival
Categories
Funding
- National Cancer Institute [R01CA112028]
- St. Louis Men's Group Against Cancer
- NATIONAL CANCER INSTITUTE [R01CA112028] Funding Source: NIH RePORTER
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Purpose of review The paucity of randomized trials comparing curative management strategies for high-risk prostate cancer makes treatment decisions in this patient population difficult. Although in the past, high-risk patients have primarily been sent for radiation therapy due to concerns that surgery was not likely to be curative and associated with high side-effect profile, there is renewed interest in radical prostatectomy as the primary treatment for high-risk disease. Recent findings Multiple case series have recently been reported that demonstrate the long-term efficacy of radical prostatectomy in a high-risk population with 15-year prostate cancer-specific survival of over 80%. Comparisons of different treatment options using nonrandomized trials demonstrate improved outcomes with surgery compared with watchful waiting or radiation therapy. Summary Radical prostatectomy is an acceptable treatment alterative, which provides long-term durable disease control for men with high-risk prostate carcinoma
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