Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 53, Issue -, Pages 151-158Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.08.006
Keywords
-
Categories
Funding
- European Research Council (ERC) under the European Union [759120]
- ANR [ANR-14-ACHN-0024]
- Agence Nationale de la Recherche (ANR) [ANR-14-ACHN-0024] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
Translation initiation in eukaryotes is a complex multistep process that requires the interplay of over a dozen protein factors together with the small ribosomal subunit (SSU) and the mRNA. During all these steps, the SSU serves as a platform for attachment, displacement and release of different molecules. In recent years, the great number of high-resolution X-ray and cryo-EM structures provided unprecedented insights into the molecular mechanism of this important process in eukaryotes. More specifically, cryo-EM became a leading technique in uncovering the structural details of this process due to exceptional advances in resolution and in image processing. Here, we briefly review cap-dependent eukaryotic translation initiation with an emphasis on its major conformational changes at several key steps during the process, unraveled thanks to the recent advances in the structural biology field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available