Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 25, Issue -, Pages 25-33Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2013.11.011
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute
Ask authors/readers for more resources
Host cell invasion is monitored by a series of pattern recognition receptors (PRRs) that activate the innate immune machinery upon detection of a cognate pathogen associated molecular pattern (PAMP). The RIG-I like receptor (RLR) family of PRRs includes three proteins RIG-I, MDA5, and LGP2 responsible for the detection of intracellular pathogenic RNA. All RLR proteins are built around an ATPase core homologous to those found in canonical, Superfamily 2 (SF2) RNA helicases, which has been modified through the addition of novel accessory domains to recognize duplex RNA. This review focuses on the structural bases for pathogen-specific dsRNA binding and ATPase activation in RLRs, differential RNA recognition by RLR family members, and implications for other duplex RNA activated ATPases, such as Dicer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available