Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 28, Issue -, Pages 105-111Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2014.08.007
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Funding
- NIH [MH0845412, GM103368-02]
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Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS or DXMS) has emerged as an important tool for the development of small molecule therapeutics and biopharmaceuticals. Central to these advances have been improvements to automated HDX-MS platforms and software that allow for the rapid acquisition and processing of experimental data. Correlating the HDX-MS profile of large numbers of ligands with their functional outputs has enabled the development of structure activity relationships (SAR) and delineation of ligand classes based on functional selectivity. HDX-MS has also been applied to address many of the unique challenges posed by the continued emergence of biopharmaceuticals. Here we review the latest applications of HDX-MS to drug discovery, recent advances in technology and software, and provide perspective on future outlook.
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