Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 22, Issue 2, Pages 187-196Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2012.01.007
Keywords
-
Categories
Funding
- DFG [SFB 803/B2]
Ask authors/readers for more resources
SNARE molecules are the core constituents of the protein machinery that facilitate fusion of synaptic vesicles with the presynaptic plasma membrane, resulting in the release of neurotransmitter. On a molecular level, SNARE complexes seem to play a quite versatile and involved role during all stages of fusion. In addition to merely triggering fusion by forcing the opposing membranes into close proximity, SNARE complexes are now seen to also overcome subsequent fusion barriers and to actively guide the fusion reaction up to the expansion of the fusion pore. Here, we review recent advances in the understanding of SNARE-mediated membrane fusion by molecular simulations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available