Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 22, Issue 5, Pages 679-688Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2012.09.002
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Funding
- Japan Ministry of Education, Culture, Sports, Science and Technology
- US National Institutes of Health [GM073913, CA164468]
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In the last decade, a number of red fluorescent proteins (RFPs) that emit orange, red, and far-red fluorescence have been isolated from anthozoans (corals), and developed through directed molecular evolution. An attractive property possessed by some FIFPs is that their red fluorescence can be turned on or modulated by illumination at specific wavelengths. Recent progress on the development of RFPs has been accompanied with detailed studies of chromophore chemistry. A thorough understanding of the molecular mechanisms involved in the post-translational modifications of red chromophores would enable scientists to design RFPs with the desired properties to advance imaging applications. This article provides a broad perspective on the chemistry and applications of RFPs.
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