Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 22, Issue 5, Pages 550-557Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2012.07.004
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Funding
- Division of Intramural Research of the National Institute of Environmental Health Sciences
- National Institutes of Health [1 ZIA ES102645-03, AI050050, HL094463, HL096972]
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Heparan sulfates (HSs) have potential therapeutic value as anti-inflammatory and antimetastasis drugs, in addition to their current use as anticoagulants. Recent advances in chemoenzymatic synthesis of HS provide a way to conveniently produce homogenous HS with different biological properties. Crystal structures of sulfotransferases involved in this process are providing atomic detail of their substrate binding clefts and interactions with their HS substrates. In theory, the flexibility of this method can be increased by modifying the specificities of the sulfotransferases based on the structures, thereby producing a new array of products.
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