Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 21, Issue 2, Pages 274-282Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2011.01.007
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Funding
- Deutsche Forschungsgemeinschaft [SFB594, SFB646, WI3285/1-1]
- Human Frontiers of Science Organization [RGY0088/2008]
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As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit and emerges at the solvent side where protein folding occurs. Despite the universality and conservation of dimensions of the ribosomal tunnel, a functional role for the ribosomal tunnel is only beginning to emerge: Rather than a passive conduit for the nascent chain, accumulating evidence indicates that the tunnel plays a more active role. In this article, we discuss recent structural insights into the role of the tunnel environment, and its implications for protein folding, co-translational targeting and translation regulation.
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