Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 21, Issue 2, Pages 265-273Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2011.01.008
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Funding
- NIH [P01 GM-62580]
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Nine different near-atomic resolution structures of icosahedral viruses, determined by electron cryo-microscopy and published between early 2008 and late 2010, fulfil predictions made 15 years ago that single-particle cryo-EM techniques could visualize molecular detail at 3-4 angstrom resolution. This review summarizes technical developments, both in instrumentation and in computation, that have led to the new structures, which advance our understanding of virus assembly and cell entry.
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