Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 21, Issue 4, Pages 517-522Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2011.07.001
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Funding
- NIH [U54GM075026-06]
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Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules.
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