Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 21, Issue 2, Pages 249-256Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.12.005
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Funding
- UK Medical Research Council [G0900116, G1000917]
- MRC [G0900116, G1000917] Funding Source: UKRI
- Medical Research Council [G0900116, G1000917] Funding Source: researchfish
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Retroviral replication depends on successful integration of the viral genetic material into a host cell chromosome. Virally encoded integrase, an enzyme from the DDE(D) nucleotidyltransferase superfamily, is responsible for the key DNA cutting and joining steps associated with this process. Insights into the structural and mechanistic aspects of integration are directly relevant for the development of antiretroviral drugs. Recent breakthroughs have led to biochemical and structural characterization of the principal integration intermediates revealing the tetramer of integrase that catalyzes insertion of both 3' viral DNA ends into a sharply bent target DNA. This review discusses the mechanism of retroviral DNA integration and the mode of action of HIV-1 integrase strand transfer inhibitors in light of the recent visualization of the prototype foamy virus intasome, target DNA capture and strand transfer complexes.
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