Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 20, Issue 1, Pages 63-69Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.01.003
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Funding
- NIDDK NIH HHS [R01 DK073394-04, R01DK073394, R01 DK073394] Funding Source: Medline
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Single molecule manipulation techniques combined with molecular dynamics simulations and protein engineering have enabled, during the last decade, the mechanical properties of proteins to be studied directly, thereby giving birth to the field of protein nanomechanics. Recent data obtained from such techniques have helped gain insight into the structural bases of protein resistance against forced unfolding, as well as revealing structural motifs involved in mechanical stability. Also, important technical developments have provided new perspectives into protein folding. Eventually, new and exciting data have shown that mechanical properties are key factors in cell signaling and pathologies, and have been used to rationally tune these properties in a variety of proteins.
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