Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 20, Issue 1, Pages 114-120Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.12.006
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Funding
- National Science Foundation [MCB-0443899, MCB-0923873]
- National Institutes of Health [R56Al081726]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0923873] Funding Source: National Science Foundation
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Genome packaging is a fundamental process in a viral life cycle. Many viruses assemble preformed capsids into which the genomic material is subsequently packaged. These viruses use a packaging motor protein that is driven by the hydrolysis of ATP to condense the nucleic acids into a confined space. How these motor proteins package viral genomes had been poorly understood until recently, when a few X-ray crystal structures and cryo-electron microscopy (cryo-EM) structures became available. Here we discuss various aspects of genome packaging and compare the mechanisms proposed for packaging motors on the basis of structural information.
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