Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 20, Issue 4, Pages 440-447Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.06.004
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Funding
- Medical Research Council
- EDICT consortium [HEALTH-F4-2007-201924]
- MRC [MC_U105674181, MC_U105663139] Funding Source: UKRI
- Medical Research Council [MC_U105663139, MC_U105674181] Funding Source: researchfish
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Members of the mitochondrial carrier family are involved in transporting keto acids, amino acids, nucleotides, inorganic ions and co-factors across the mitochondrial inner membrane. The transporters are thought to share the same structural fold, which consists of six trans-membrane alpha-helices and three matrix helices, arranged with threefold pseudo-symmetry. During the transport cycle two salt bridge networks on either side of the central cavity might regulate access to a single substrate binding site in an alternating fashion. In the case of proton-substrate symporters the substrate binding sites contain also negatively charged residues that are proposed to be involved in proton transport.
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