Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 20, Issue 4, Pages 527-532Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.06.001
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- Agency for Science, Technology and Research (Singapore)
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The conversion of biomass to fuels and chemicals faces substantial challenges if it is to be done on a large scale, in a sustainable manner, and at reasonable cost. Some of these challenges can be addressed through protein engineering technologies, for example by improving biomass-processing enzymes or by manipulating the activities and substrate specificity of enzymes in metabolic pathways. Recent highlights include structure-guided chimera design to improve the properties of cellulases, the engineering of synthetic scaffold proteins to enhance metabolic flux, and the broadening of substrate specificity to co-opt metabolic pathways to the production of long-chain branched alcohols.
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