Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 20, Issue 1, Pages 90-97Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.12.001
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Funding
- Howard Hughes Medical Institute
- National Institutes of Health
- Damon Runyon Cancer Research Foundation
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Virtually all animals and plants utilize small RNA molecules to control protein expression during different developmental stages and in response to viral infection. Structural and mechanistic studies have begun to illuminate three fundamental aspects of these pathways: small RNA biogenesis, formation of RNA-induced silencing complexes (RISCs), and targeting of complementary mRNAs. Here we review exciting recent progress in understanding how regulatory RNAs are produced and how they trigger specific destruction of mRNAs during RNA interference (RNAi).
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