Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 20, Issue 2, Pages 142-147Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.12.004
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Funding
- National Institutes of Health
- National Science Foundation
- Howard Hughes Medical Institute
- CTBP
- University of Texas Medical School at Houston
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Guanine and adenine nucleotide triphosphatases, such as Ras proteins and protein kinases, undergo large conformational changes upon ligand binding in the course of their functions. New computer simulation methods have combined with experimental studies to deepen our understanding of these phenomena. In particular, a 'conformational selection' picture is emerging, where alterations in the relative populations of preexisting conformations can best describe the conformational switching activity of these important proteins.
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