Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 19, Issue 6, Pages 666-671Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.09.004
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/B/14426] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/B/14426] Funding Source: Medline
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Thioesters, amides, and esters are common chemical building blocks in a wide array of natural products. The formation of these bonds can be catalyzed in a variety of ways. For chemists, the use of an activating group is a common strategy and adenylate enzymes are exemplars of this approach. Adenylating enzymes activate the otherwise unreactive carboxylic acid by transforming the normal hydroxyl leaving group into adenosine monophosphate. Recently there have been a number of studies of such enzymes and in this review we suggest a new classification scheme. The review highlights the diversity in enzyme fold, active site architecture, and metal coordination that has evolved to catalyze this particular reaction.
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