Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 19, Issue 6, Pages 740-745Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.10.005
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Funding
- National Agency for Research
- Association pour la Recherche Sur le Cancer
- Association Francaise contre les Myopathies
- Region Ile-de-France
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Recent advances in elucidating the structure of yeast Pol I and III are based on a combination of X-ray crystal analysis, electron microscopy and homology modelling. They allow a better comparison of the three eukaryotic nuclear RNA polymerases, underscoring the most obvious difference existing between the three enzymes, which lies in the existence of additional Pol-I-pecific and Pol-III-specific subunits. Their location on the cognate RNA polymerases is now fairly well known, suggesting precise hypotheses as to their function in transcription during initiation, elongation, termination and/or reinitiation. Unexpectedly, even though Pol I and III, but not Pol II, have an intrinsic RNA cleavage activity, it was found that TFIIS Pol II cleavage stimulation factor also played a general role in Pol III transcription.
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