Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 19, Issue 3, Pages 329-334Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.03.011
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Funding
- NIGMS NIH HHS [P01 GM063208-01A1, P01 GM063208] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM063208] Funding Source: NIH RePORTER
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In this, the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the Origin of Species, it is fitting to revisit the classification of protein structures from an evolutionary perspective. Existing classifications use homologous sequence relationships, but knowing that structure is much more conserved that sequence creates an iterative loop from which structures can be further classified beyond that of the domain, thereby teasing out distant evolutionary relationships. The designed classification scheme is then one in which a fold is merely semantics and structure can be classified as either ancestral or derived.
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