Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 19, Issue 3, Pages 260-266Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.04.002
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI089826] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050313] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI089826] Funding Source: Medline
- NIGMS NIH HHS [R01 GM050313-15, R01 GM050313] Funding Source: Medline
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Intron splicing is a fundamental biological process whereby noncoding sequences are removed from precursor RNAs. Recent work has provided new insights into the structural features and reaction mechanisms of two introns that catalyze their own splicing from precursor RNA: the group I and II introns. In addition, there is an increasing amount of structural information on the spliceosome, which is a ribonucleoprotein machine that catalyzes nuclear pre-mRNA splicing in eukaryotes. Here, we compare structures and catalytic mechanisms of self-splicing RNAs and we discuss the possible implications for spliceosomal reaction mechanisms.
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