Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 19, Issue 4, Pages 473-482Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.07.003
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Funding
- NIGMS NIH HHS [R01 GM053329, R01 GM053329-12] Funding Source: Medline
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Fusion of HIV-1 and target cells is mediated by the envelope protein gp41 that undergoes a series of conformational changes during the process of infection. Knowledge of the structural biology of gp41 allows the design of potent peptide inhibitors that prevent the virus from entering lymphocytes and macrophages. The design of such inhibitors is the subject of this review.
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