Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 3, Pages 305-314Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.05.002
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Funding
- NIGMS NIH HHS [P01 GM066275-05, P01 GM066275] Funding Source: Medline
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The rapid development of our understanding of the diverse biological roles fulfilled by non-coding RNA has motivated interest in the basic macromolecular behavior, structure, and function of RNA. We focus on two areas in the behavior of complex RNAs. First, we present advances in the understanding of how RNA folding is accomplished in vivo by presenting a mechanism for the action of DEAD-box proteins. Members of this family are intimately associated with almost all cellular processes involving RNA, mediating RNA structural rearrangements and chaperoning their folding. Next, we focus on advances in understanding, and characterizing the basic biophysical forces that govern the folding of complex RNAs. Ultimately we expect that a confluence and synergy between these approaches will lead to profound understanding of RNA and its biology.
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