Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 1, Pages 106-111Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2007.12.010
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM071504, R01 GM071504-01A2, GM071504] Funding Source: Medline
Ask authors/readers for more resources
Iron homeostasis in animal cells is controlled post-transcriptionally by the iron regulatory proteins IRP1 and IRP2. IRP1 can assume two different functions in the cell, depending on conditions. During iron scarcity or oxidative stress, IRP1 binds to mRNA stem-loop structures called iron responsive elements (IREs) to modulate the translation of iron metabolism genes. In iron-rich conditions, IRP1 binds an iron-sulfur cluster to function as a cytosolic aconitase. This functional duality of IRP1 connects the translational control of iron metabolizing proteins to cellular iron levels. The recently determined structures of IRP1 in both functional states reveal the large-scale conformational changes required for these mutually exclusive roles, providing new insights into the mechanisms of IRP1 interconversion and ligand binding.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available