Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 3, Pages 342-348Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.02.004
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM083107] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01GM083107, R01 GM083107-01A1, R01 GM083107] Funding Source: Medline
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Depending on whether similar structures are found in the PDB library, the protein structure prediction can be categorized into template-based modeling and free modeling. Although threading is an efficient tool to detect the structural analogs, the advancements in methodology development have come to a steady state. Encouraging progress is observed in structure refinement which aims at drawing template structures closer to the native; this has been mainly driven by the use of multiple structure templates and the development of hybrid knowledge-based and physics-based force fields. For free modeling, exciting examples have been witnessed in folding small proteins to atomic resolutions. However, predicting structures for proteins larger than 150 residues still remains a challenge, with bottlenecks from both force field and conformational search.
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